“Hold My Halo” (Lainey Wilson, Derek George, Monty Criswell, Lynn Hutton)Ĩ. “Me, You, and Jesus” (Lainey Wilson, Emily Weisband, Dallas Wilson)ħ. “Weak-End” (Lainey Wilson, Nicolette Hayford, Faren Rachels)Ħ. “Grease” (Lainey Wilson, Jessi Alexander, Andrew Petroff)ĥ. “Watermelon Moonshine” (Lainey Wilson, Jordan Schmidt, Josh Kear)Ĥ. ![]() “Road Runner” (Lainey Wilson, Trannie Anderson, Dallas Wilson)ģ. “Hillbilly Hippie” (Lainey Wilson, Terri Jo Box, Jeremy Bussey)Ģ. Lainey Wilson ‘Bell Bottom Country’ Photo Courtesy of Alyssa Gafkjenġ. The album, which will blend the elements of ‘70s Rock, Funk and Soul while remaining true to her Country roots, will also display her growth as an artist and songwriter. The project will allow Wilson’s authenticity to vibrantly shine through the vulnerable and empowering lyrics. “Sure, I love a good pair of bell-bottoms, but Bell Bottom Country to me has always been about the flare and what makes someone unique - I have really embraced mine, and I hope y’all can hear that across this project.”īell Bottom Country is derived from the moniker folks use to describe Wilson’s unique sound, style and aesthetic - it’s Country, but with a flare. “I’ve lived quite a bit of life the past few years, and I have a lot more to say,” Wilson shared of the new album. Her sophomore album will also feature a tribute to her “Deddy” and a cover of 4 Non Blondes classic hit “ What’s Up (What’s Going On).” Wilson co-wrote every song on the album except for the 4 Non Blondes cover. The 14-track project will include her latest single “ Heart Like A Truck” and the just-released tune, “Watermelon Moonshine.” Wilson is also gearing up to release her highly anticipated new album, Bell Bottom Country. ![]() Lainey Wilson Is Gearing Up To Release Her Sophomore Album, Bell Bottom Country It also became the most-added song at country radio with 57 first-week stations when it went for adds on Monday, August 29. The news comes after the release of Wilson’s collaboration with HARDY, “ Wait In The Truck,” which was an instant hit upon its debut. The 56th Annual CMA Awards winners will be revealed on November 9 during a three-hour ABC broadcast, which begins at 8 P.M. Thank you to the entire country music community! #CMAawards /zdYp42tvtD While I try to find the words just know that I’m blown away and so so honored and proud to be nominated. Thank you to the entire country music community!”Ħ NOMINATIONS!?!? I’m speechless. ”While I try to find the words just know that I’m blown away and so, so honored and proud to be nominated. “6 NOMINATIONS!?!? I’m speechless,” Wilson wrote. Upon hearing the exciting news, Wilson took to social media to graciously thank the Country music community for their votes. “It has been such a challenging but beautiful journey up until this point and to see the Country music community and the incredible fans be so receptive to me and my music is such a blessing. “This is my first time being cordially invited to the CMA Awards as a nominee and what a wonderful invitation it is,” Wilson said in a press release. Other artists to achieve this milestone included Kacey Musgraves (2013), Brad Paisley (2000), and Glen Campbell (1968). The “ Watermelon Moonshine” singer is now the fourth artist in CMA Awards history to earn six nominations with their debut on the ballot. The fast-rising country star leads the pack of nominees with nominations in the following categories: Album of the Year (Sayin’ What I’m Thinkin’), Female Vocalist of the Year, Music Video of the Year (“Never Say Never”), Musical Event of the Year (“Never Say Never”), New Artist of the Year, Song of the Year (“Things A Man Oughta Know”). 7) as she made a historic debut on the CMA Awards’ final ballot with six nominations as a first-time nominee. Lainey Wilson claimed a piece of country music history on Wednesday (Sept.
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![]() Legal experts at the Senate Ways and Means Committee say the new law makes the decision largely moot, since the SJC clarified the 2018 law, but the Legislature has written a new law governing marijuana-related expungements. The court ruling did not mention the 2022 law change. The court clarified that expungement should be done on a record-by-record basis, so if someone was convicted of a traffic violation and marijuana possession, documents related to the traffic stop could be kept in the record but redacted to remove references to marijuana. Georges added: “If no substantial countervailing concern is raised, judges must grant the petition for expungement if a concern is raised, judges who chose to deny motions for expungement in response to those concerns must make written findings as to the basis of their decisions.” ![]() ![]() The court concluded that people seeking to have records expunged for marijuana offenses that have since become legal “ are entitled to a strong presumption in favor of expungement,” and petitions may be denied “only if a significant countervailing concern is raised in opposition to the petition.” While the Legislature allowed some judicial authority, Georges wrote that “should not be understood as a grant of broad authority.” Instead, he said, a judge has discretion to account for “rare countervailing factors that the Legislature could not anticipate with precision.” The SJC, in a 28-page unanimous decision written by Justice Serge Georges, overruled the Boston judge, saying the judge abused his discretion. But a Boston Municipal Court judge denied both requests for expungement, finding that expunging the records was not “in the best interests of justice.” petitioned for expungement so the records would be eliminated, not just hidden from public view. But after the Legislature passed the criminal justice reform law, K.W. He pleaded guilty to three charges, including marijuana possession. He gave the police another person’s driver’s license and was found to be driving with a suspended license and in possession of two bags of marijuana. was a passenger in a car that was stopped for traffic violations, and a pat frisk found a small plastic bag of marijuana on him. K.W., as the petitioner is referred to in court documents, sought to expunge criminal records stemming from two arrests involving possession of small amounts of marijuana. If the petitioner or district attorney requests a hearing, a judge must make written findings of fact why they are granting or denying the petition.Ī Supreme Judicial Court ruling issued Thursday related to a judge’s interpretation of the 2018 law. Charlie Baker signed in August removed that judicial discretion and said a court “shall” within 30 days of receiving a petition order the expungement of a record for marijuana possession, cultivation, or distribution of an amount of marijuana that has been decriminalized. The law, however, gave judges discretion in deciding whether to grant an expungement based on “what is in the best interests of justice.” The 2018 criminal justice reform law let criminal records be expunged if the underlying conduct was no longer a crime – the main application being possession of small amounts of marijuana. ![]() Is there a way to ensure the BitLocker To Go Reader is not installed on FAT-formatted drives?Ĭan I save files to my BitLocker-protected removable drive when I am using Windows XP or Windows Vista?Ĭan I download a copy of the BitLocker To Go Reader? What happens if I try to open a BitLocker-protected, NTFS-formatted removable drive by using a computer running Windows XP or Windows Vista? How can I authenticate or unlock my removable data drive?Ĭan I use BitLocker To Go with computers running Windows XP or Windows Vista? How are the PIN and TPM used to derive the volume master key? ![]() How can I evaluate a TPM's dictionary attack mitigation mechanism?Ĭan PIN length and complexity be managed with Group Policy? How does BitLocker help prevent an attacker from discovering the PIN that unlocks my operating system drive? Why do I have to use the function keys to enter the PIN or the 48-character recovery password? What encryption keys are used in BitLocker? How do they work together? If I lose my recovery information, will the BitLocker-protected data be unrecoverable?Ĭan the USB flash drive that is used as the startup key also be used to store the recovery key?Ĭan I save the startup key on multiple USB flash drives?Ĭan I save multiple (different) startup keys on the same USB flash drive?Ĭan I generate multiple (different) startup keys for the same computer?Ĭan I generate multiple PIN combinations? Is it possible to add an additional method of authentication without decrypting the drive if I only have the TPM authentication method enabled? How can the recovery password and recovery key be stored? What is the difference between a TPM owner password, recovery password, recovery key, PIN, enhanced PIN, and startup key? What if my disk configuration is not listed? What type of disk configurations are supported by BitLocker? Why is "Turn BitLocker on" not available when I right-click a drive? What causes BitLocker to start into recovery mode when attempting to start the operating system drive?Ĭan I swap hard disks on the same computer if BitLocker is enabled on the operating system drive?Ĭan I access my BitLocker-protected drive if I insert the hard disk into a different computer?Ĭan I dual boot Windows 7 and Windows Vista with BitLocker-protected operating system drives? What system changes would cause the integrity check on my operating system drive to fail? How can I prevent users on a network from storing data on an unencrypted drive? Why does it appear that most of the free space in my drive is used when BitLocker is converting the drive?ĭoes BitLocker encrypt and decrypt the entire drive all at once when reading and writing data? What happens if the computer is turned off during encryption or decryption? Is there a noticeable performance impact when BitLocker is enabled on a Windows 7–based computer?Īpproximately how long will initial encryption take when BitLocker is turned on? What is the difference between disabling, suspending, and decrypting when I turn off BitLocker?ĭo I have to decrypt my BitLocker-protected drive to download and install system updates and upgrades?Ĭan BitLocker deployment be automated in an enterprise environment?Ĭan BitLocker encrypt more than just the operating system drive? What versions of Windows 7 include BitLocker? Can I use BitLocker on a Windows XP–based computer?Ĭan I upgrade my Windows XP–based computer to Windows 7 with the necessary disk configuration for BitLocker?Ĭan I upgrade my Windows Vista–based computer to Windows 7 with BitLocker enabled? What credentials are required to use BitLocker? How do I obtain BIOS support for the TPM on my computer? How can I tell whether my computer has a TPM version 1.2?Ĭan I use BitLocker on an operating system drive without a TPM version 1.2? Which Trusted Platform Modules (TPMs) does BitLocker support? Why are two partitions required? Why does the system drive have to be so large? What are the BitLocker hardware and software requirements? Overview and requirementsĭoes BitLocker support multifactor authentication? For frequently asked questions about BitLocker in Windows Vista, see Windows BitLocker Drive Encryption Frequently Asked Questions. This topic includes frequently asked questions about BitLocker in Windows 7. BitLocker Drive Encryption is a data protection feature available in Windows 7 Enterprise, Windows 7 Ultimate, and in all editions of Windows Server 2008 R2. After training you can instantly re-visit the registered shots in our data and analysis platform."ĪLABA FREE KICK GOLAZO WITH HIS FIRST TOUCH OF THE MATCH □ /Bto4ZoMMsb- ESPN FC August 14, 2022Īnd there's already evidence to suggest it's paying dividends for Real Madrid on the pitch. You configure which players need to jump. "You configure the heights of the players via our app. "You select the number of players to set up the wall: four, five or six," Debets told ESPN. The device is controlled via tablet, with a series of variables allowing for a more authentic imitation of the scenarios players like Modric, Dani Ceballos, Vinicius Junior and Toni Kroos - all featured in the video - will encounter during a game. The amount of requests has been insane, really." ![]() "Obviously with Real Madrid posting their free kick training sessions, interest has gone through the roof. If we show them our videos, it's self-explanatory," Debets said. "There's not a single club that isn't interested. Madrid's video going viral on social media - with a million views on Twitter and over 700,000 likes on Instagram - has predictably increased demand. It's confirmation that our innovation is being accepted by the world of football." To have such a world-class club embracing our product makes us really proud. "We delivered the product in Madrid and demonstrated the use of FreeKickPro during one of their training sessions. "During the summer we connected with Real Madrid and Davide," Debets told ESPN. It is an application layer protocol for message exchange between clients and. Madrid assistant coach Davide Ancelotti - son of manager Carlo - is always on the lookout for new ideas to keep training sessions fresh. Dls Roma Forma UrlJuventus 2018-19 Dream League Soccer kits logo 512x512 URL. ☄ coup franc, 20 mètres : ça donne ça □⤵ /6QuhFWyJNO- Olympique Lyonnais July 18, 2022 The company have worked with several Dutch clubs including local giants PSV Eindhoven and Feyenoord, as well as Lyon in France, and linked up with Real Madrid in July this year. They just never had the right equipment to train properly. "We don't have to explain to anyone in the world of football the importance of a free kick. Stream on ESPN+: LaLiga, Bundesliga, MLS, more (U.S.) With FreeKickPro they can replicate this situation one or two days prior to the game. "Clubs already know the probability of where they will most likely get a free kick during their next match, and the behaviour of their opponent's wall. "FreeKickPro lets you configure the actual wall of any opponent with identical behaviour," Debets said. Twitter the never-ending search for marginal gains, the robotic wall is a big step up from the same old flat, plastic outlines of players that even some elite clubs have been using for years. "The training situation has absolutely nothing to do with the resistance players experience in a game: the height of the players, the number of players, the visibility and ability to jump." Real Madrid midfielder Luka Modric is just one of the player using the robotic wall to deliver set pieces more efficiently. "With all the innovation in the world of football, the way every club in the world trains, one of the most decisive parts of the game has never evolved from yellow mannequins," FreeKickPro's Machiel Debets told ESPN. France 2018 World Cup Kits & Logo URL Dream League Soccer ( https://dlscenter. The company behind it are FreeKickPro, based in Valkenswaard, a town just outside Eindhoven in the Netherlands. Customize your DLS or FTS15 team with the Manchester Uniteds kits and logo. ![]() Twitter the most high-profile showcase yet for this latest training-ground innovation, but Madrid aren't the only ones taking advantage of this new technology. Real Madrid's robotic wall is a sign of how technology is being incorporated into training to help players and teams prepare for game scenarios. This is Madrid's new robotic free kick wall, which caused quite a stir when the club posted a video showing off their fancy new gadget on social media last week. It isn't made up of real players, for a start, despite their humanoid form - sculpted torsos bearing this season's Real Madrid kits - and perfectly-timed upward movement. The five-man wall jumps to meet the delivery but it curls high, up and over their heads and into the net.īut wait a minute. Wear the jersey of the iconic club of the French capital.He takes three short steps before striking the ball right-footed. Haz clic o touch en el botn de 'Saltar Publicidad' y se abrir una ventana con el kit. ![]() 2.Se abrira una ventana con publicidad espera que termine el conteo y/o activa la casilla 'No soy Robot'. Paris Sain Germain Shirts, Jersey and Football Kits 2021/ 2022 the official kits of the Paris Saint Germaine. 1.-Haz clic o touch en la imagen del kit que desees. ![]() Paris Saint Germain (PSG) Kits 2022 Jordan – Dream League Soccer 21 Kits. If you reboot, check the device names before restarting ddrescue. Some systems may change device names on reboot (e.g.If you use a device or a partition as destination, any data stored there will be overwritten.Never try to repair a file system on a drive with I/O errors you will probably lose even more data.It is best that the device or partition to be rescued is not mounted at all, not even read-only. Never try to rescue a r/w mounted partition.You need to understand what it does, and you need to understand some things about the machines it does those things to, in order to use it safely. GNU ddrescue is like any other power tool.This is why it can be helpful to have the DDRescue-GUI and optionally, GParted, to provide a better visual check before you might destroy the existing data on a destination drive!įrom the GNU ddrescue Manual, all emphasis mine! You should take care to remember that any data on a chosen destination will be replaced. In this case unmount the drive if you mounted it and try to recover an image of all you can onto a new good drive, ideally of the same capacity and form factor if it is destined to be a replacement for a broken computer. You should allow the tools you run to finish, avoid running them on mounted partitions and never try to repair data on suspected damaged drives. With any tool capable of erasing data, there is the opportunity to make a mistake that results in the source data being damaged. Please read this or risk losing your data! You probably came here because of a data recovery issue. Ubuntu 22.04 LTS shipped with release 1.23 which is a little behind the current release, but for LTS users I would recommend sticking with the release provided with the LTS distribution unless you absolutely know you need a fix made in the current release. As is often the case your distribution might be a little behind the upstream release. GNU ddrescue is an essential tool for data recovery originally released in 2004 and consistently updated by the original author. It copies data from one file or block device (hard disc, cdrom, etc) to another, trying to rescue the good parts first in case of read errors. Grow your knowledge of Linux.GNU ddrescue is a data recovery tool. Join us here and on IRC Freenode #tinycorelinux. The Tiny Core Linux Team currently consists of eight members who peruse the forums to assist from answering questions to helping package new extensions. Anyone can contribute to our project by packaging their favorite application or hardware support to run in Tiny Core. We promote community involvement and community built application extensions. Within our forums we have an open developement model. We invite interested users and developers to explore Tiny Core. While Tiny Core always resides in ram, additional applications extensions can either reside in ram, mounted from a persistent storage device, or installed into a persistent storage device. The desktop boots extremely fast and is able to support additional applications and hardware of the users choice. Our goal is the creation of a nomadic ultra small graphical desktop operating system capable of booting from cdrom, pendrive, or frugally from a hard drive. The latest version: 13.1 News About Our Project The user has complete control over which applications and/or additional hardware to have supported, be it for a desktop, a netbook, an appliance, or server, selectable by the user by installing additional applications from online repositories, or easily compiling most anything you desire using tools provided. It represents only the core needed to boot into a very minimal X desktop typically with wired internet access. It is not a complete desktop nor is all hardware completely supported. ![]() Maintaining the Core principal of mounted extensions with full package management. Tin圜ore becomes simply an example of what the Core Project can produce, an 16MB FLTK/FLWM desktop.ĬorePlus ofers a simple way to get started using the Core philosophy with its included community packagedĮxtensions enabling easy embedded frugal or pendrive installation of the user's choice of supported desktop, while Tin圜ore is Core + Xvesa.tcz + Xprogs.tcz + aterm.tcz + fltk-1.3.tcz + flwm.tcz + wbar.tcz It starts with a recent Linux kernel, vmlinuz, and our root filesystem and start-up scripts packaged with a basic set of kernel modules in core.gz.Ĭore (11MB) is simply the kernel + core.gz - this is the foundation for user created desktops, servers, or appliances. The Core Project is a highly modular based system with community build extensions. Welcome to The Core Project - Tiny Core Linux ![]() Important Notices of Regulatory Violations.This means that the original author of the song has the power to: Normally, the audio tracks that streamers use in their games are usually protected by copyright. However, in many cases, they use music without any knowledge of the consequences that this innocent act can have. At the same time, online streams of multimedia content are growing too.Īmong the most important platforms that broadcast content about video games are YouTube Gaming and Facebook Gaming, but the undisputed leader in this sector is still Twitch.Īccording to the Twitch Tracker portal, this streaming platform has gone from 300,000 unique users per month in 2012 – its first year – to 3.8 million streamers per month in 2020.ĭuring their broadcasts, a large number of these users use background music, either to concentrate on the game or for sharing their favorite music with their followers. ![]() Musical content YOU CAN NOT use in Twitchįor several years, the video game industry is growing by leaps and bounds.Restrictions on the use of music in Twitch.Compared to the electronic cityscape music, classical, ambient and similarly structured tracks seem more suited to this aesthetic. Overall it feels right that the time lapse background music should match that sense of breath. They show rarely-seen moments unfolding with an organic ebb and flow-almost like the picture is breathing-that is certainly very different from the city footage. One Green Planet has a collection of ten beautiful nature films nearly all follow this principle. The reason has to do again with the visual. But whereas that push for electronica worked perfectly for an urban view, a natural vista is usually paired with something calmer and more relaxed. In fact, the speed at which it’s shown in the time lapse is the natural world’s equivalent to a thumping rave. Contrarily, in time lapse, this process appears like a slow and graceful ballet. One minute the flower buds are closed, and then the next, they’re open. Unlike the busy go-go-go of the city, a natural process in time lapse, like a flower blooming, poses a different paradox. It’s not extremely fast, but it has a relentless feel to it, just like Singapore’s notorious work culture. ![]() It’s a buzzing, driving, electronic beat. The soundscape certainly matches this landscape. The visual is hypnotic and undeniably busy, like a metallic bee hive. It uses a mix of filming techniques to create a vision of a futuristic city that’s practically robotic in its forward drive. For urban hyperlapse footage, for example, As an illustration, check out a gorgeous film of Singapore’s skyline, Lion City II – Majulah, by Keith Loutit. But does up-tempo time lapse background music really work?Īs a matter of fact, it can work great, if the visual is right. ![]() As a result, it can be tempting to put the soundtrack on fast forward as well, like a comedy chase theme tune. To put it unelegantly, it’s fast forward, in essence. It’s footage of something that normally is very slow being shown sped up to an extreme extent. The thing about time lapse video is that it’s basically a study in extreme contrast. ![]() Wait till MVP gets behind him! Naoya Inoue self explanatory. Not a big enough name for them to risk losing. “David Benavidez is being ducked by everyone in his weight class and has obliterated top level talent which puts him on the list as arguably one of the most feared people in the sport. How can you not have undisputed champions on your lists?! Y’all are goofy. Also it’s a sin to have someone who just lost on your list. “Moving on, y’all can’t have your lists with people like Vasyl Lomachenko who doesn’t even hold a belt in that weight class which puts Devin Haney on this actually good list that is the real pound-for-pound list moving forward. “Shakur Stevenson making easy work of everyone in his weight class and knocking down Valdez is such a statement," Paul added. He also took aim at The Ring Magazine 's pound-for-pound list, which includes Vasyl Lomachenko ahead of Haney despite him not holding any belts with any major governing bodies. But he feels that Stevenson is like a "young Floyd " and is confident that he will be a world champion at further weight classes.ĭo you agree with Jake Paul's pound-for-pound list? Let us know your thoughts in the comments section below! Paul is friendly with Stevenson and Haney, with the undisputed lightweight champion appearing on an early episode of his show 'BS with Jake Paul'. We all know it’d be the exact same fight at 168lbs which bumps Canelo off this list, plus Canelo is ducking David Benavidez and Jermall Charlo." He also reasoned why Alvarez isn't on the list, adding: "Bivol knocks Canelo Alvarez off the list not only for beating him at 175lbs but for being willing to go to 168lbs. Bivol being in the same weight class also means they need to settle who is better." ![]() Artur Beterbiev is the only current champion who has all KOs and it is not talked about enough. Terrence and Errol is obvious and it all just needs to be settled. "However, what Usyk has done from cruiserweight to heavyweight has been impressive and his dominance, versatility and boxing ability is second to none. Jake Paul claims he is ready to fight Tommy Fury with February agreement reached ![]() "He beats every heavyweight by TKO or KO including Usyk and there hasn't been a heavyweight in the sport that hasn't fallen off eventually but Tyson Fury is still on top and I expect him to retire on top. "First and foremost, Tyson Fury has been the most dominant heavyweight in the division for so long," Paul explained. Jermell Charlo is No.8 on the list, with David Benavidez at No.9 and Naoya Inoue in the final sport. Paul placed the recently-stripped super-featherweight world champion Shakur Stevenson at No.6, ahead of No.7 Devin Haney, who is the undisputed champion in Stevenson's new lightweight division. He didn't include Canelo Alvarez at all, placing his fighter Amanda Serrano in tied fifth with Katie Taylor. The YouTuber-turned-boxer has named Fury as the pound-for-pound No.1, with his fellow heavyweight champion Oleksandr Usyk down as low as No.4 under the tied pairs of Terrence Crawford and Errol Spence and Artur Beterbiev and Dmitry Bivol. Your awesome" - Amy 2020 Superbowl Commercial Logos Bingo Cards 2020 Superbowl Commercial Logos Bingo Cards Game, Printable All PDF Readers $2.Jake Paul has ranked Tyson Fury as the greatest boxer in the world in his pound-for-pound top 10 list - while also including three extra names. "Thank you so much for generating such a genius Super Bowl Bingo card! 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Innan du kan börja använda cDock måste du inaktivera SIP på Mac om du kör macOS El Capitan 10.11 eller senare. ![]() You can also try the GUI method for applications including the Finder. cDock är en tredjepartslösning som lägger till massor av inställningar för att anpassa din docka. Screenshot: You can also use the GUI to force quit applications Screenshot: You can also use the GUI to force quit applications Or, try the GUI method Hardware: All LaCie storage products are compatible with Mac OS 10.11, except for the 5big Thunderbolt 2 and the 8bigThunderbolt 2, which require a firmware. Jakmile deaktivujete SIP, mete pokraovat stáhnte si cDock jako obvykle a otevete jej. Jak zakázat SIP, jsme se zabývali v jednom z naich dívjích píspvk. This incarnation of OS X has improved security and control. Ne budete moci zaít pouívat cDock, budete muset zakázat SIP na Macu, pokud pouíváte macOS El Capitan 10.11 nebo novjí. Mac OS X 10.11 El Capitan is a new version of Apples juggernaut line of operating systems providing the only alternative to Microsoft Windows. … or, Ctrl-Option-Click the Finder icon in the Dock. Download Cdock For El Capitan Office 2016 For Mac Catalina Google Earth For Mac Yosemite Is Sierra Better Than El Capitan For Osx 10.11.6. Menubar restart killall -KILL SystemUIServerĭock or Spaces restart killall -KILL Dock Notifications System restart killall -KILL NotificationCenter If you find yourself with a hung Mac Notifications system, Menu-bar, Finder or Dock, just start up Terminal (hint: just type “Terminal” in Spotlight and press Enter), and issue the appropriate command. What to do when OSX’s Menubar, Finder or Dock Crashes Want to discover art related to cdock Check out amazing cdock artwork on DeviantArt. Unlike the Dock, however, we havent yet found a way to adjust the time delay between when your cursor hits the top of the screen and the Menu Bar appears. Drag its icon off the Dock and onto the Desktop. Get inspired by our community of talented artists. Removing an item from the Dock is as easy as 1-2-3 but without the 3: 1. Has your Mac OS X menubar, Dock, Finder or notifications system crashed? These very simple Terminal commands let you restart each, tested OK from OS X version 10.8.3 through 10.11.3 as of. Check out amazing cdock artwork on DeviantArt. ![]() Val122Ile variant carrier had a higher risk of all-cause mortality (HR: 1.44 P=0.0004) compared with non-carriers. The incidence of all-cause mortality (per 1000 person-years) was 41.5 (95% CI: 34.6–49.7) among variant carriers and 33.9 (95% CI: 32.7–35.2) among variant non-carriers. Val122Ile variant carriers had a higher risk of incident HF (HR: 2.46 P<0.0001) compared with non-carriers. The incidence of HF (per 1000 person-years) was 15.9 (95% CI: 11.5–21.9) among variant carriers and 7.2 (95% CI: 6.6–7.9) among variant non-carriers. We used multivariable-adjusted Cox regression models accounting for demographic, clinical, and social factors, and genetic African ancestry to assess the risk of incident HF and all-cause mortality among those carrying TTR Val122Ile genetic variation compared with those without the variation.Īmong 7,514 Black participants (median age: 64 years 61% females), the population frequency of the TTR Val122Ile variant was 3.1% (232 carriers 7,282 non-carriers). Poisson regression was used to estimate the rates of incident HF and all-cause mortality. We evaluated self-reported Black American participants of the REGARDS study without HF at baseline. We evaluated the Black participants from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study to examine the association of TTR Val122Ile mutation with HF and all-cause mortality. Estimation of the effect of this amyloidogenic TTR variant on the risk of heart failure (HF) and all-cause mortality in a large, geographically diverse cohort of Black Americans may provide insight into the clinical significance of this variant. Genetic mutation in the TTR gene (rs76992529 Val122Ile) seen exclusively in individuals with African ancestry (population frequency: 3–4%) causes misfolding of the tetrameric transthyretin protein complex that accumulates as extracellular amyloid fibrils seen in hereditary transthyretin amyloidosis (hATTR). ![]() #2 Association of transthyretin Val122Ile variant with incident heart failure and mortality among Black Americans: insights from the regards studyġUniversity of Alabama at Birmingham, Birmingham, ALĤWeil Cornell Medical Center, New York, NY IGF1 potentially exerts its atheroprotective effect via this reduction in CXCL12 by reducing monocyte recruitment and by increasing ABCA1, thereby increasing cholesterol efflux capacity. Our results indicate that macrophage IGF1 reduces atherosclerosis and decreases CXCL12, a chemokine newly implicated in atheroprogression. We also found a 27% increase in cholesterol efflux in IGF1 (100 ng/mL) treated THP-1 cells with Apolipoprotein AI as a cholesterol acceptor. We loaded peritoneal macrophages with oxLDL to measure changes in cholesterol efflux and found that MF-IGF1 mice have a 42% increase in efflux. We found that peritoneal macrophages isolated from MF-IGF1 mice have a 2 fold increase in ABCA1 protein levels. IGF1 completely blocked oxidized low-density lipoprotein (oxLDL)-dependent increase of CXCL12 mRNA transcription (98% reduction, P<0.01) and IGF1 treatment reduced CXCL12 protein (56% decrease, P<0.001) in vitro.ĪTP-binding cassette transporter A1 (ABCA1) is the key cholesterol transporter mediating macrophage cholesterol efflux and CXCL12 reduces its expression. CXCL12 protein levels were reduced in plaque and peritoneal macrophages in MF-IGF1 mice. Monocyte recruitment was reduced by 70% in MF-IGF1 mice and was associated with a 27% reduction in circulating levels of CXC Chemokine Ligand 12 (CXCL12). Macrophage IGF1 overexpression downregulated plaque burden by 30%, reduced plaque macrophages by 47%, and promoted features of a stable plaque phenotype. We also assessed cholesterol efflux and foam cell formation in vivo and in vitro. We accelerated atherosclerotic development by feeding animal a high fat diet for three months. We hypothesized that increasing IGF1 levels strictly in macrophages will prevent atherosclerosis.Īfter breeding a novel macrophage-specific IGF1 overexpressing transgenic mouse to an Apoe -/- background (MF-IGF1 mice), we assessed atherosclerotic plaque burden, stability, and monocyte recruitment. ![]() Results of our previous in vitro experiments suggest that macrophages play a predominant role in mediating IGF1 effects in atherosclerotic plaque, but exact mechanisms remain unclear. IGF1 administration in ApoE deficient (Apoe -/-) mice fed a high fat diet reduced atherosclerosis and reduced plaque macrophages. Insulin Like Growth Factor I (IGF1) has been shown to reduce cardiovascular events. 1Tulane University School of Medicine, New Orleans, LAĢUniversity of Missouri System, Columbia, MOĪtherosclerosis is the leading cause of Cardiovascular Disease, which is still the global leader of mortality. |
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